Craniofacial morphology in Apert syndrome: a systematic review and meta-analysis.

This meta-analysis aims to compare Apert syndrome (AS) patients with non-AS populations (not clinically or genetically diagnosed) on craniofacial cephalometric characteristics (CCC) to combine publicly available scientific information while also improving the validity of primary study findings. A comprehensive search was performed in the following databases: PubMed, Google Scholar, Scopus, Medline, and Web of Science, an article published between 1st January 2000 to October 17th, 2021. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed to carry out this systematic review. We used the PECO system to classify people with AS based on whether or not they had distinctive CCC compared to the non-AS population. Following are some examples of how PECO has been used: People with AS are labeled P; clinical or genetic diagnosis of AS is labeled E; individuals without AS are labeled C; CCC of AS are labeled O. Using the Newcastle-Ottawa Quality-Assessment-Scale, independent reviewers assessed the articles' methodological quality and extracted data. 13 studies were included in the systematic review. 8 out of 13 studies were score 7-8 in NOS scale, which indicated that most of the studies were medium to high qualities. Six case-control studies were analyzed for meta-analysis. Due to the wide range of variability in CCC, we were only able to include data from at least three previous studies. There was a statistically significant difference in N-S-PP (I2: 76.56%; P = 0.014; CI 1.27 to - 0.28) and Greater wing angle (I2: 79.07%; P = 0.008; CI 3.07-1.17) between AS and control subjects. Cleft palate, anterior open bite, crowding in the upper jaw, and hypodontia occurred more frequently among AS patients. Significant shortening of the mandibular width, height and length is the most reported feature in AS patients. CT scans can help patients with AS decide whether to pursue orthodontic treatment alone or to have their mouth surgically expanded. The role of well-informed orthodontic and maxillofacial practitioners is critical in preventing and rehabilitating oral health issues.

Ectopic Eye Tooth Management: Photobiomodulation/Low-Level Laser Emission Role in Root Resorption after Fixed Orthodontic Treatment.

Aim: This study evaluates the role of low-level laser emission/photobiomodulation (LE/P) in quantitative measurements of root resorption (QRR). The application of LE/P performed after each orthodontic activation with four types of treatment intervention (TI) on the root resorption (RR) after fixed orthodontic treatment (FOT) of the upper arch with ectopic eye tooth/teeth [EET] was investigated. Materials and Methods: Thirty-two orthodontic patients scheduled for FOT were selected and assigned to the four groups. These were LE/P + Self ligating bracket (SLB), LE/P + Conventional bracket (CB), non-photobiomodulation (non-LE/P) + SLB and non-LE/P + CB. Standard management stages of FOT were followed in the maxilla. Each patient received a single application of LE/P labially/buccally and palatally, a total of five different points were used during each activation or appointment. The main outcome measure was QRR in maxillary anteriors before and after FOT, assessed via cone-beam computed tomography (CBCT) using 3D OnDemand software. Results: Insignificant QRR was found between before and after FOT in SLB, CLB, and LE/P, non-LE/P groups (p > 0.05). QRR in the SLB vs. CB and LE/P vs. non-LE/P group was significantly different in 11, 13, and 23 (p < 0.05). QRR in the LE/P + SLB group (p < 0.05) was significantly different in 11, 13, and 23 than that in the other groups. The most severe QRR was found on 13 (0.88 ± 0.28 mm and 0.87 ± 0.27 mm) and 23 (1.19 ± 0.14 mm and 1.16±0.13 mm) in the CB and non-LE/P group (p < 0.001). LE/P + SLB showed a highly significant superior outcome (p < 0.001) in relation to non-LE/P + CB, the QRR of 23 were 0.813 ± 0.114 mm and 1.156 ± 0.166 mm, respectively. Conclusion: Significantly higher amounts of QRR were found in EET patients after FOT treated with the CB, non-LE/P, and non-LE/P + CB system and warrant further investigation to explore potential specific causes.

Reliability of dentin translucency and incremental cemental lines in age estimation using light and stereomicroscopes: A comparative study.

Age estimation of the dead and human remains has been challenging in forensic medicine, both in mass disasters and criminal investigations. There are several approaches to accurately evaluate age, each with its own benefits and drawbacks. Dentine translucency (DT) and incremental cemental lines (ICL) have often been used for age estimation in living adults and unknown skeletal remains. We attempted to estimate age using both these parameters and compare accuracy of age estimated using these parameters in a larger sample. A total of 300 extracted single-rooted permanent teeth were collected from the patients aged between 15 and 75 years. Longitudinal ground sections in the buccolingual direction of 250 µm thickness were prepared, and the images obtained were subsequently analyzed to measure the length of DT using the ImageJ software program. In addition, the number of ICL were also counted in each tooth section. The age of the individuals was estimated using both methods individually, and the results have shown that both parameters have shown reliable age estimates in the middle age groups. However, there was overestimation of age up to 10.6 years in the younger age group using DT and an underestimation of age up to 13.4 years in the older age group with ICL. Pearson's correlation statistics revealed a strong positive and statistically significant correlation of both the parameters with the chronological age (0.973 and 0.917). To conclude, the method using the ICL should be preferred due to the relatively higher number of errors (<±3 years) which were considered excellent.

Periodontal Clinical Parameters as a Predictor of Bite Force: A Cross-Sectional Study.

OBJECTIVE: To investigate the correlation of periodontal parameters and bite force in different stages of periodontitis after phase I periodontal therapy. METHODS: Periodontal clinical parameters such as mobility, attachment loss, gingival recession, and percentage of bone remaining were recorded at the mandibular first molar region after phase I therapy in subjects categorized according to the stage of periodontitis. Corresponding bite force was recorded at the first mandibular molar region using a bite force device after phase I therapy. ANOVA test was used to assess the significant difference among different groups. Pearson correlation coefficient was used to assess the correlation between measured variables. RESULTS: The ANOVA test represents that there is no statistical significant difference between the bite force in stage I, stage II, and stage III type of periodontitis. A strong positive correlation was found (r = 0.537) between bite force and percentage of remaining alveolar bone support whereas negative correlation was observed in measured parameters such as mobility (r = -0.0181), attachment loss (r = -0.608), and gingival recession (r = -0.435). CONCLUSION: Among all periodontal clinical parameters, the percentage of remaining alveolar bone is the strong predictor of bite force and mobility; attachment loss and gingival recession cannot predict the bite force in the first molar region. Bite force is variable in different stages of periodontitis.

Prevalence of Peg-Shaped Lateral Incisors in Non-Syndromic Subjects: A Multi-Population Study

Abstract Objective: To evaluate the prevalence and gender-wise distribution of peg-shaped maxillary permanent lateral incisors among populations in Saudi Arabia representing different geographical locations (Saudi, Jordan, Egypt, Syria, Philippine, Pakistan, India and Bangladesh). Material and Methods: Panoramic radiographs of 9945 patients attending outpatient university dental clinics of College of Dentistry, Jouf University, Saudi Arabia between February 2014 and January 2018 were collected from the archives randomly. Two calibrated investigators examined the data, which were collected from the dental radiology department archives with prior permission from the authorities. The anomalies of maxillary lateral incisors (right and left) were investigated. Results: Among all geographic locations, the prevalence of peg laterals was more in males in comparison to females except in Pakistani and Philippine populations. Among the Saudi population, peg laterals' prevalence was more in case of right lateral incisor than the left incisor. Conclusion: A higher prevalence of peg laterals was found in Saudi. Conclusion: A higher prevalence of peg laterals was found in Saudi region, followed by Egypt. Among all geographic locations, the prevalence of peg laterals was higher in males than females except for Pakistan and Philippines populations. Among Saudi population prevalence of peg laterals was found to be higher in case of right lateral incisor when compared to the left.

Comparative evaluation of micronuclei in saudi smokers and non-smokers without any visible oral lesions: a pilot study / Evaluación comparativa de micronúcleos en fumadores y no fumadores sauditas sin lesiones orales visibles: un estudio piloto

Objectives: A systematic review was conducted to evaluate effectiveness and safety of beta carotenes for the treatment of oral leukoplakia regarding clinical resolution and prevention of malignant transformation. Material and Methods: The systematic search was conducted in three electronic databases and the study's selection was performed according to pre-set eligibility criteria. Four studies evaluating the efficacy of beta carotenes in oral leukoplakia compared to placebo were included in the review; three of which were assigned for quantitative analysis. Data were extracted, tabulated, quality assessed and statistically analyzed. Results: The meta-analysis revealed that when comparing clinical resolution the beta carotene group favored was favored compared to placebo, with statistically significant difference. However, a meta-analysis comparing beta carotene and placebo groups regarding malignant transformation as a primary outcome failed to show any significant benefit. Furthermore, results showed evidence of beta carotene safety. Conclusion: the overall quality of evidence about efficacy of beta carotene in oral leukoplakia treatment was not high. However, given the obvious safety of this agent, data suggests it could have a promising effect in clinical improvement of oral leukoplakia lesions. However, no evidence supporting its benefits in reducing risk of malignant transformation in these lesions was found. Therefore, further long term, well designed randomized clinical trials are highly recommended.

Introducción: el cáncer oral es un problema grave con alta mortalidad y morbilidad, a pesar de la disponibilidad de los mejores tratamientos. Uno de los factores más importantes para una mortalidad tan alta es su diagnóstico tardío. La mejor manera de enfrentar un problema de este tipo es evitar su aparición creando conciencia entre la población y tenendo un diagnóstico más temprano. El cáncer oral es una enfermedad multifactorial, donde el daño genómico tiene un papel. Se ha demostrado que los micronúcleos (MNi) son un biomarcador importante y en este estudio se utilizó como una herramienta para crear conciencia sobre el riesgo de cáncer oral. Objetivo: evaluar y comparar la frecuencia de MNi en fumadores sin ninguna lesión oral visible (Grupo I) y no fumadores sanos (Grupo II). Materiales y métodos: se obtuvieron citoestimuladores de fumadores sauditas (n = 15, Grupo I) sin ninguna lesión oral visible y no fumadores sanos (n = 15, control, Grupo II) y se tiñeron con hemotoxilina y eosina para evaluar la frecuencia de MNi y las observaciones fueron sometidas a análisis estadístico utilizando la prueba t de Student. Resultados: La frecuencia media de MNi en el Grupo I fue significativamente mayor (p<0.05) que en el Grupo II. El estudio ayuda a educar, motivar y crear conciencia, alentando así a los pacientes a dejar de fumar, y evitando así el cáncer oral antes de su inicio.